Rapid DNA vaccination against Burkholderia pseudomallei flagellin by tattoo or intranasal application
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چکیده
منابع مشابه
Rapid DNA vaccination against Burkholderia pseudomallei flagellin by tattoo or intranasal application
Melioidosis is a severe infectious disease with a high mortality that is endemic in South-East Asia and Northern Australia. The causative pathogen, Burkholderia pseudomallei, is listed as potential bioterror weapon due to its high virulence and potential for easy dissemination. Currently, there is no licensed vaccine for prevention of melioidosis. Here, we explore the use of rapid plasmid DNA v...
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Yao-Shen Chen, Ssu-Ching Chen, Tsu-Rong Wu, Chih-Ming Kao and Ya-Lei Chen* Section of Infectious Disease, Kaohsiung Veterans General Hospital, Graduate Institute of Environmental Education and Department of Biotechnology, National Kaohsiung Normal University, Department of Medical Technology, Fooyin Unversity, Institute of Environmental Engineering, National Sun Yat-Sen University, Kaohsiung, T...
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The plasmid DNA encoding the fliC gene of Burkholderia pseudomallei combined with CpG oligodeoxynucleotide (ODN) was injected intramuscularly into BALB/c mice, resulting in the increased production of certain humoral antibodies and flagellin-specific spleen cell clonal expansion. CpG ODN, as an immunoadjuvant, was added to the plasmid containing the fliC gene in order to obtain ongoing expressi...
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Burkholderia pseudomallei is a Gram-negative bacillus that is the causative agent of melioidosis. The bacterium is inherently resistant to many antibiotics and mortality rates remain high in endemic areas. The lipopolysaccharide (LPS) and capsular polysaccharide (CPS) are two surface-associated antigens that contribute to pathogenesis. We previously developed two monoclonal antibodies (mAbs) sp...
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The Gram-negative facultative intracellular rod Burkholderia pseudomallei causes melioidosis, an infectious disease with a wide range of clinical presentations. Among the observed visceral abscesses, the liver is commonly affected. However, neither this organotropism of B. pseudomallei nor local hepatic defense mechanisms have been thoroughly investigated so far. Own previous studies using elec...
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ژورنال
عنوان ژورنال: Virulence
سال: 2017
ISSN: 2150-5594,2150-5608
DOI: 10.1080/21505594.2017.1307485